We occasionally use the phrase "jacked up" at work. This is somewhere between "on vulture precautions" and "train wreck", and is a source of confusion for those people not versed in the cynical and bitter humor of a neuroscience unit. Therefore, I present examples of "jacked up" and "not jacked up" for your perusal. It is to be hoped that they will clarify the issue.
Migas: not jacked up.
Migas with store-bought pico de gallo: jacked up.
Hole in your belly I could put my head through: not jacked up.
Hole in your belly secondary to an abcess that's been cooking for twenty years, ever since you had gastric stapling: jacked up.
Hemiparetic after a stroke: most definitely not jacked up.
Hemiparetic and in respiratory distress: potentially severely jacked.
Spontaneous Creutzfeld-Jakob disease: jacked up. No question.
Asshole third-year resident: not jacked up, as there is still hope.
Asshole third-year resident in peer review: irretrievably jacked up.
Twinkies: total jacked-uppery.
Deep fried Twinkies with Hershey's syrup: not jacked up.
Fractured pelvis and dislocated hip: only semi-jacked-up.
Fractured pelvis, dislocated hip, history of polio: jacked. Up.
Nurse on day one of a three-day week: not jacked up.
Nurse on day three of a three-day week: jacked up.
Having a kneecap kicked off by a horse: jacked up.
Getting inadvertently stepped on by a one-ton bull: not jacked up.
Brain tumor: depends. If it's a meningioma: not jacked up. Glioblastoma multiforme? Jacked.
I hope that's a little clearer now.